University of Cambridge > Talks.cam > Biological and Statistical Physics discussion group (BSDG) > Neurotransduction mechanism via GPCRs: alpha helix, the smallest spring in nature?”

Neurotransduction mechanism via GPCRs: alpha helix, the smallest spring in nature?”

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If you have a question about this talk, please contact Salvatore Tesoro.

A two part presentation demonstrates the use of computational methods in deciphering reaction mechanisms of protein-ligand interactions. The first part presents an example of a ligand as inhibitor. A statistical mechanical framework based on Inhomogeneous Fluid Solvation Theory is used to determine underlying mechanism of potency of an inhibitor toward a protein. The second part presents an example of a ligand as agonist. A mechanism of nerve signal transduction via GPC Rs is proposed. It is based on idea that a neurotransmitter interacts with not only residues of a protein but with its helical backbone structure. This interaction triggers a conformational change between 3-10 and 4-13 forms of the helix, in other words helix springs. Discussion on fundamentally opposing modes of mechanisms between ligands (inhibitors and agonists), as well as between proteins (enzymes and receptors, where one changes the ligand while the other changes itself), will close the talk.

This talk is part of the Biological and Statistical Physics discussion group (BSDG) series.

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