University of Cambridge > Talks.cam > Microsoft Research Cambridge, public talks > Genome-wide transcriptional control of blood cell type identity

Genome-wide transcriptional control of blood cell type identity

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Microsoft Research Cambridge Talks Admins.

This event may be recorded and made available internally or externally via http://research.microsoft.com. Microsoft will own the copyright of any recordings made. If you do not wish to have your image/voice recorded please consider this before attending

Transcription factors (TFs) have long been recognised as important regulators of blood cell type identity. Despite advances in the generation of TF binding maps by ChIP-seq, not much is known about the genome-wide impact of TF binding in driving transcriptional programs of multiple cell types. In particular, the rules that govern functional TF binding remain unclear and much remains to be learned about the mechanisms of combinatorial TF interactions, including to what extent constrained spacing and orientation of interacting TFs are critical for regulatory element activity and cell type-specific gene regulation. A more comprehensive understanding of the molecular mechanisms of transcription, however, is recognized to have broad implications for cellular reprogramming and medicine. Using genomics technology, genome sequence analysis and statistical modelling, this study provided greater insight into the role of transcription factors in establishing and maintaining distinct cell-type identity during the process of blood cell maturation. In-depth analysis demonstrated that shared TFs actively participate in the transcriptional programmes of distinct cell types and TFs preferentially bind with constrained spacing.

This talk is part of the Microsoft Research Cambridge, public talks series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2019 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity