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Whole-genome analysis of the structure and function of repressive chromatin

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Several types of chromatin protein complexes are thought to mediate repression of transcription, often by packaging of DNA into compact structures. We have begun a systematic genome-wide analysis of the genomic binding patterns of the most important repressive complexes: “classical” heterochromatin proteins, Polycomb Group proteins, histone H1, and nuclear lamina proteins. These genome-wide maps provide detailed and often surprising insights into the functions and interactions of these complexes.

This talk is part of the European Bioinformatics Institute series.

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