University of Cambridge > Talks.cam > MRC LMB Seminar list > Protein folding homeostasis in the endoplasmic reticulum: tuning a chaperone

Protein folding homeostasis in the endoplasmic reticulum: tuning a chaperone

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

A transcriptional and translational program that strives to match the complement of chaperones in the endoplasmic reticulum (ER) to the burden of unfolded proteins in the early secretory pathway (the Unfolded Protein Response) has long been known to exist and its functional importance has been showcased by genetic and pharmacological manipulations. However, theoretical considerations supported by experimental observations highlight the latency inherent in this gene expression program and suggest the potential importance of post-translational adaptations that operate on a shorter time scale. This seminar will review some recent observations pertaining to an ER-localized circuitry that tunes the activity of the compartment’s resident Hsp70 protein, BiP, to rapid fluctuations in unfolded protein load.

This talk is part of the MRC LMB Seminar list series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2020 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity