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Generators of diversity and the host-pathogen interface

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Dr Nina Papavasiliou, The Rockefeller Institute, New York

Migratory cells travel through ever changing environments. Assessment of, and adaptation to these changes is necessary for survival. At the population level, heterogeneity within cellular subsets functions to both empower the host immune response, and evade it (e.g. in the case of pathogens).

We study two mechanisms that generate informational diversity within cells: DNA shuffling or mutation, and RNA editing, and I’ll discuss examples of how these impact the host-pathogen interaction.

This talk is part of the Immunology in Pathology series.

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