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Alzheimer’s Disease: Addressing a Twenty-First Century Plague

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Neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases arguably represent the greatest challenge to the social fabric and health care systems of much of the modern world. The most common neurodegenerative disorders are associated with protein misfolding and aggregation, and they therefore differ in nature from most other types of disease and indeed there are at present no cures or even highly effective treatments. Very signicant advances have, however, been made recently in our knowledge of the molecular origins of these conditions, and are now beginning to suggest new and rational therapeutic strategies by which to combat their onset and progression. This talk will discuss recent approaches to this end that we are currently exploring within the framework of our growing mechanistic understanding of the fundamental nature of protein misfolding and aggregation.

Professor Chris Dobson is the John Humphrey Plummer Professor of Chemical and Structural Biology at the University of Cambridge, and Master of St John’s College. His research activities are primarily concerned with discovering the fundamental origins of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, with the objective of identifying new strategies for their prevention or treatment. He is a Fellow of the Royal Society, the Royal Society of Chemistry and the Academy of Medical Sciences, and a Foreign Associate of the US National Academy of Sciences.

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This talk is part of the The Blackett Society series.

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