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How cryo-EM is revolutionising structural biology

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Recent advances in direct-electron detectors and advanced image processing algorithms have resulted in cryo-EM structure determination to near-atomic resolution for a wide range of macromolecular complexes. I will discuss these advances and illustrate their potential by presenting our results on gamma-secretase. This intra-membrane protease cleaves many substrates, and is perhaps best known for producing amyloid-beta peptides, abundant deposits of which in the brain are a defining characteristic of Alzheimer’s disease.

This talk is part of the Biophysical Seminars series.

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