"The Implications of Differential Clustering for the Analysis of Binary Outcome Measures"

Add to your list(s) Download to your calendar using vCal

• Dr Chris Roberts, University of Manchester
• Tuesday 23 February 2016, 14:30-15:30
• Large Seminar Room, 1st Floor, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge.

If you have a question about this talk, please contact Alison Quenault.

Abstract: In trials of non-pharmacological treatments clustering of patients may occur due to randomisation or due to the nesting of patients in therapist or therapy groups. This talk will consider the implication of heterogeneity of the clustering effect where the outcome measure is binary.

Heterogeneity of the clustering effect may arise in trials of group administered or therapist treatment where a clustered therapy is compared with a placebo or pharmacological control. This leads to what has been called a partially nested design where there is clustering in one arm but not the comparator.

Heteroscedasticity of the clustering effect can arise in cluster randomised trials. Statistical analysis of cluster randomised trials generally assumes that the intra-cluster correlation coefficient (ICC) is the same in all arms. This assumption can be justified by randomisation provided the clustering effect is due to the baseline characteristics. If, instead, the magnitude of the clustering effect is caused by the intervention, the ICC may differ between trial arms.

After reviewing the situation where the outcome measure is continuous, the robustness of methods of analysis for binary outcomes will be considered.

This talk is part of the MRC Biostatistics Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• BHRU Annual Lecture 2015
• BHRU Annual Lecture 2016
• Biology
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge Immunology
• Cambridge talks
• Cardiovascular Epidemiology Unit Special Seminars
• Chris Davis' list
• Department of Public Health and Primary Care
• Graduate-Seminars
• Interested Talks
• Large Seminar Room, 1st Floor, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge
• Life Sciences
• Life Sciences
• ME Seminar
• MRC Biostatistics Unit Seminars
• Primary Care
• PublicHealth@Cambridge
• Trust & Technology Initiative - interesting events
• bld31
• my_list
• ndk22's list
• ob366-ai4er
• other talks
• primary care
• rp587

Note that ex-directory lists are not shown.