Exploiting single-cell fluctuations

Add to your list(s) Download to your calendar using vCal

• Johan Paulsson (Harvard University)
• Wednesday 20 January 2016, 09:00-09:45
• Seminar Room 1, Newton Institute.

If you have a question about this talk, please contact INI IT.

SDBW01 - Opening workshop

All intracellular processes involve components present in low numbers, creating spontaneous fluctuations that in turn can enslave the components present in high numbers. The mechanisms often appear complex, with reaction rates that depend nonlinearly on concentrations, indirect feedback loops, and distributed delays. Most systems are also sparsely characterized, with a few steps known in detail but many important interactions not even identified. In the first half of the talk, I will discuss mathematical approaches that exploit natural fluctuations to more reliably analyze data and to make predictions about what complex biological networks cannot do. In the second half I will discuss some of our recent experimental results on the role of fluctuations in cells, e.g. in the segregation of mitochondria, oscillations of synthetic genetic networks, bacterial cell fate decisions, and DNA repair.

This talk is part of the Isaac Newton Institute Seminar Series series.

This talk is included in these lists:

• All CMS events
• Featured lists
• INI info aggregator
• Isaac Newton Institute Seminar Series
• School of Physical Sciences
• Seminar Room 1, Newton Institute
• bld31

Note that ex-directory lists are not shown.