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Aspects of bacterial persistence

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SDBW01 - Opening Workshop

Bacterial persistence is probably the best-established example of a system where noisy gene expression provides a fitness benefit. By inducing switching between two phenotypes, one well-adapted to growth-promoting conditions and one adapted to survival in hostile conditions, noise allows provides a mechanism that allows a population to deal with unpredictable environmental conditions. In the talk I will discuss the gene circuits and feedback underlying persistence, aspects of the evolution of these circuits as well as how such heterogeneity of the population can be advantageous for the spreading of a population in space.

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