The cutting edge of Alzheimer’s disease research

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• Prof. Bart De Strooper, University of Leuven and University College London
• Wednesday 01 June 2016, 10:30-11:30
• Department of Chemistry, Cambridge, Unilever lecture theatre.

If you have a question about this talk, please contact Jerome Charmet.

All welcome

Alzheimer’s Disease is characterized by the progressive accumulation of amyloid peptides in amyloid plaques and Tau peptides in neuronal tangles spread over the brain. This proteopathic stress induces a complex cascade of cellular reactions which leads over a period of several decades to clinical dementia. The disease appears to be very difficult to model in non-primate species. In my seminar I will cover two topics. First I will speak about the proteases that are responsible for the initial generation of the amyloid peptide and how targeting them might yield preventative therapy for Alzheimer Disease. Second I will discuss a novel in vivo model for Alzheimer Disease. I will show how human neurons transplanted into a mouse brain loaded with amyloid peptide recapitulate important features of the disease.

Ref: De Strooper and Karran. The cellular phase of Alzheimer Disease, Cell 2016.

This talk is part of the Biophysical Seminars series.

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