University of Cambridge > Talks.cam > Cambridge Cardiovascular Seminar Series > Traditional and Genetic Risk Factors for Coronary Heart Disease: First versus Subsequent Events

Traditional and Genetic Risk Factors for Coronary Heart Disease: First versus Subsequent Events

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Patients with coronary heart disease (CHD) have high long-term morbidity and mortality, yet our ability to identify or intervene in those at greatest risk is limited. Risk factors for subsequent CHD events have been understudied with an assumption that they are likely to precisely overlap with those for first CHD events. Our group is testing the hypothesis that differences in risk factor associations in these two settings could exist, which in turn may inform (1) better risk prediction (2) mechanistic insights and (3) new drug development for secondary prevention. We are examining, at scale, the association of selected genetic and phenotypic CHD risk factors with risk of subsequent events by utilizing previously unavailable resources, harnessing large scale data through linked electronic health records of 10 million UK patients, a new global consortium of CHD cohorts with DNA and the UK Biobank.

This talk is part of the Cambridge Cardiovascular Seminar Series series.

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