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University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > Dynamics of DNA base-pair breathing, telomere loss and telomere clustering
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If you have a question about this talk, please contact info@newton.ac.uk. SDBW04 - Spatially distributed stochastic dynamical systems in biology We start by analysing a model of base-pair breathing in DNA using a system of stochastic ordinary differential equations to describe the distances between bases in a sequence of bases that contains a defect. We describe how the parameters in the SODE model are obtained from all-atom MD simulations (AMBER) using a maximum likelihood algorithm. The result is a model which explains how base-pair breathing depends on the twist of the double helix. This work is in collaboration with Cipri Duduiala, Ian Dryden and Charlie Laughton (Phys Rev E, 80, 061906, 2009 and Physica D 240, 1254-1261, 2011). This talk is part of the Isaac Newton Institute Seminar Series series. This talk is included in these lists:
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