University of Cambridge > Talks.cam > Genetics Seminar  > Defining transcription units across the human genome.

Defining transcription units across the human genome.

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Host: Michaela Frye

The dramatic achievement of sequencing the whole human genome has been tempered by the subsequent realisation that the human transcriptome is far more complex than initially anticipated; far from any clear understanding of how and why it is made. My lab has focused on the basic mechanism of transcriptional termination and associated RNA 3 ’ end processing by the major RNA polymerase II (Pol II) that is responsible for the synthesis of all pre messenger RNA and most non coding RNAs. We have uncovered a surprising diversity of termination mechanisms using gene specific analyses. We are now applying new native elongating transcription (NET) sequencing strategies to define all Pol II transcription units (especially mammalian NET -seq). Using this technology we are uncovering unanticipated mechanistic cross talk between the basic transcription process and associated pre-mRNA and long non coding RNA processing.

This talk is part of the Genetics Seminar series.

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