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Transcriptional and phenotypic variability in response to temperature in plants

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The regulation of gene expression is often noisy rather than being uniform. Identical cells can oscillate between different transcriptional burst states, such that at any one time they are likely to have quite different gene expression behaviours. However the mechanisms and potential biological roles of transcriptional noise are still poorly understood. The widespread nature of this behaviour has lead to propose that transcriptional noise is beneficial under stress conditions. Up to now, most studies on the role of transcriptional noise have been performed in unicellular organisms or in cell cultures and little is known about the role of transcriptional noise and how transcriptional noise is controlled in a multicellular organism. We are analysing transcriptional noise between cells and between individuals in response to environment using the plant model species Arabidopsis thaliana combining transcriptomic and microscopy approaches.

This talk is part of the Computational and Systems Biology series.

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