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"The roles of alternative splicing in regulating the function of intrinsically disordered regions"

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Alternative splicing (AS) generates extensive transcriptomic complexity. However, how this myriad of detected AS events contribute to biological functionality is not well understood. In this talk, I will describe how exons regulated by alternative splicing show a strong tendency to modulate low affinity and transient short linear motif (SLiM)-mediated protein-protein interactions. I will illustrate this with an example of a mammalian-specific set of AS events. These events regulate the inclusion of repetitive GY-SLiMs within nearly all members of the heterogeneous nuclear ribonucleoprotein (hnRNP) A and D families of RNA binding proteins. The differential inclusion of these exons impacts the formation of hnRNP-driven higher-order protein assemblies required for the regulation of target AS events.

This talk is part of the Babraham Seminar series.

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