University of Cambridge > Talks.cam > European Bioinformatics Institute > Mapping Variation in Humans and Yeast

Mapping Variation in Humans and Yeast

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Nicholas Luscombe.

Note different room

We have been mapping structural and regulatory variation in yeast and humans. In humans we have used two approaches, (1) high density tiling arrays and (2) a novel high throughput sequencing strategy to map structural variations in human DNA . We have identified large number of copy number and other variations throughout the human genome. We have also applied the high resolution array technology to mapping chromosomal rearrangements in genetic diseases.

We have also compared transcription factor binding sites within different isolates of yeast and different species. We find extensive variation in transcription factor binding between closely related species. Overall our studies demonstrate considerable structural and regulatory variation between members of a given species and between species.

Korbel JO et al. Paired-end mapping reveals extensive structural variation in the human genome. Science. 2007 Oct 19;318(5849):420-6.

Borneman AR et al. Divergence of transcription factor binding sites across related yeast species. Science. 2007 Aug 10;317(5839):815-9.

This talk is part of the European Bioinformatics Institute series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2019 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity