Separation Control in Over-expanded Supersonic Nozzles: Improving the Performance of Ballistic Drug and Vaccine Delivery Devices

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• Dr Maynard Marrion BPI
• Thursday 11 October 2007, 11:30-12:30
• Open Plan Area, BP Institute, Madingley Rise CB3 0EZ.

If you have a question about this talk, please contact Anne Alexander.

Lunch will be provided after the seminar

Abstract: Systems for the ballistic delivery of drugs and vaccines have been developed by the Department of Engineering Science at Oxford University in collaboration with PowderJect Pharmaceuticals plc. In these devices micro-particles of pharmaceutical agent are accelerated by a supersonic gas flow to velocities sufficient for them to penetrate the outer layers of the skin. Under certain conditions shock waves form in the gas stream and cause boundary layer separation and global disruption of gas-particle flow leading to sub-optimal drug delivery. An experimental study of the conditions required for shock wave formation and of the consequent disrupted flow field was performed. Then the formation of the shock wave was then postponed and/or the separation suppressed by application of either boundary layer or global control mechanisms to the flow.

This talk is part of the Institute for Energy and Environmental Flows (IEEF) series.

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• Institute for Energy and Environmental Flows (IEEF)
• NanoDTC Energy Materials Talks
• Open Plan Area, BP Institute, Madingley Rise CB3 0EZ
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