An intracellular organization of extracellular information

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• Prof. Peter Swain, University of Edinburgh
• Friday 17 November 2017, 16:00-17:00
• Small Lecture Theatre, Cavendish Laboratory.

If you have a question about this talk, please contact Lorenzo Di Michele.

Although cells respond specifically to environments, how environmental identity is encoded intracellularly is not understood. Here I will discuss this organization of information in budding yeast by estimating the mutual information between environmental transitions and the dynamics of nuclear translocation for ten transcription factors. Information is transduced through two channels – generalists and specialists – and transcription factors report differently and collectively can provide more information than predicted by noise-averaging. Changes in nuclear localization of multiple transcription factors thus constitute a precise, multi-dimensional internal representation of complex environments.

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