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Genomic principles for feedback regulation of metabolism

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Small molecule metabolism is the highly coordinated interconversion of chemical substrates through enzyme-catalysed reactions. It is central to the viability of all organisms as it enables the assimilation of nutrients for energy production and the synthesis of precursors for all cellular components. The system is tightly regulated so cells can respond efficiently to environmental changes. This is optimised to minimise the substantial cost of enzyme production and core metabolite depletion, and to maximise the benefit of cell growth and division. It is commonly known that this regulation is achieved by controlling either (i) the availability of enzymes or (ii) their activities. Though the molecular mechanisms behind these two regulatory processes have been elucidated in great detail, and we still lack insight into how they are deployed and complement each other at a global level. Here, I will present a genome-scale analysis of how regulatory feedback by small molecules control the metabolic system, and examine how the two modes of regulation are deployed throughout the system.

Bio: Nick Luscombe, Group Leader, EMBL -European Bioinformatics Institute Nick completed his PhD with Professor Janet Thornton at University College London (1996-2000), studying the basis for specificity of DNA -binding proteins. He then moved to Yale University as a post-doctoral fellow with Professor Mark Gerstein (2000-2004). During this time, he shifted his research focus to genomics, with a particular emphasis on yeast transcription regulation. He has been a Group Leader at EMBL -EBI since 2005, examining the regulation of interesting biological systems.

This talk is part of the Computer Laboratory Systems Research Group Seminar series.

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