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"A TREMendous mechanism for Alzheimer's Disease: therapeutic insights"

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TREM2 is arguably the most potent genetic risk factor for sporadic Alzheimer’s disease. It is a scavenger receptor recognising generic molecular patterns on cellular debris and amyloid fibrils. Reduced levels of TREM2 on the surface of the brain’s phagocytic cells, the microglia, is associated with disease risk. Protecting TREM2 from proteolytic shedding from the microglial surface is a potential therapeutic goal.

This talk is part of the Biophysical Seminars series.

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