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mTOR and Lysosomes in Growth Control

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David Sabatini is a Member of the Whitehead Institute for Biomedical Research, and a Professor of Biology at the Massachusetts Institute of Technology. He is also an Investigator of the Howard Hughes Medical Institute, a Senior Associate Member at the Broad Institute and a member of the Koch Institute for Integrative Cancer Research, and an American Cancer Society Research Professor.

David and his lab study the basic mechanisms that regulate cell growth. A major focus of the lab is the Target of Rapamycin (TOR) pathway, a major regulator of growth in many eukaryotic species. This has resulted in the identification of many components of the pathway and to an understanding of their cellular and organismal functions, most of which have implications for diseases such as cancer and diabetes. David is also interested in the role of metabolism in cancer and in the mechanisms that control the effects of dietary restriction on tumorigenesis. Additionally, his lab has developed new technologies that facilitate the analysis of gene function in mammalian cells.

David received his B.S. from Brown University magna cum laude and his M.D./Ph.D. from Johns Hopkins University. He has received numerous honors and awards, some of which are the 2009 Paul Marks Prize, the 2014 NAS Award in Molecular Biology, the 2017 Lurie Prize in Biomedical Sciences, and the 2017 Dickson Prize in Medicine. He was elected to the National Academy of Sciences in 2016.

This talk is part of the Seminars at the Department of Biochemistry series.

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