BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//talks.cam.ac.uk//v3//EN
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
CATEGORIES:Microsoft Research Symposium
SUMMARY:From microscopic to macroscopic descriptions of ce
ll migration on growing domains - Dr Ruth Baker\,
University of Oxford
DTSTART;TZID=Europe/London:20090602T171000
DTEND;TZID=Europe/London:20090602T180000
UID:TALK17884AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/17884
DESCRIPTION:*Abstract*: Cell migration and growth are essentia
l components of the development of multicellular o
rganisms. The role of various cues in directing ce
ll migration is widespread\, in particular\, the r
ole of signals in the environment in the control o
f cell motility and directional guidance. In many
cases\, especially in developmental biology\, grow
th of the domain also plays a large role in the di
stribution of cells and\, in some cases\, cell or
signal distribution may actually drive domain grow
th. There is a ubiquitous use of partial different
ial equations (PDEs) for modelling the time evolut
ion of cellular density and environmental cues. In
the last twenty years\, a lot of attention has be
en devoted to connecting macroscopic PDEs with mor
e detailed microscopic models of cellular motility
\, including models of directional sensing and sig
nal transduction pathways. However\, domain growth
is largely omitted in the literature.\nIn this ta
lk\, individual-based models describing cell movem
ent and domain growth are outlined\, and correspon
dence with a macroscopic-level PDE describing the
evolution of cell density is demonstrated. The ind
ividual-basedmodels are formulated in terms of ran
domwalkers on a lattice. Domain growth provides an
extra mathematical challenge by making the lattic
e size variable over time. A reaction-diffusion ma
ster equation formalism is generalised to the case
of growing lattices and used in the derivation of
the macroscopic PDEs.\n\n*Biography*: Ruth Baker
is an RCUK Academic Fellow in Mathematical Biology
at the Centre for Mathematical Biology\, part of
the Mathematical Institute\, University of Oxford.
She is a Junior Research Fellow at St Hugh’s Coll
ege and holds a Microsoft Research European Fellow
ship. She has also held a Lloyds Tercentenary Foun
dation Fellowship.\n\nRuth completed her M.Math (1
997-2001) and D.Phil (2001-2005) at Wadham College
and also held a Stipendiary Lectureship in Applie
d Mathematics at St John’s College (2004-2005).
LOCATION:Large public lecture room\, Microsoft Research\, R
oger Needham Building\, 7 J J Thomson Avenue\, Cam
bridge CB3 0FB
CONTACT:Dr Fabien Petitcolas
END:VEVENT
END:VCALENDAR