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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Cell-based modelling for wound contraction and ang
iogenesis - Vermolen\, F (Delft University of Tech
nology)
DTSTART;TZID=Europe/London:20151103T110000
DTEND;TZID=Europe/London:20151103T120000
UID:TALK62240AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/62240
DESCRIPTION:Wound contraction and angiogenesis are biological
processes that often take place during healing of
wounds and in tumor development. To model these pr
ocesses\, one distinguishes between different type
s of models\, which are descriptive at several sca
les\, ranging from cellular scale (micro-scale) to
the tissue scale (macro-scale). The models are on
the macro-scale are based on continuum hypotheses
\, which means that one sets up and solves partial
differential equations with the associated bounda
ry and initial conditions. On the smallest scale o
ne models all kinds of cell phenomena on a molecul
ar level. In this talk\, we will consider colonies
of cells\, which are treated as discrete entities
\, as well as chemical and mechanical signals that
are modelled as sets of partial differential equa
tions. Hence\, the current approach is a hybride o
ne. \n\nThe process of angiogenesis\, which is the
formation of a vascular network in tissues\, is o
ften modeled by using principles based on cell den
sities in a continuum approach or on hybride cellu
lar-continuum level where one uses cellular automa
ta (in particular cellular Potts) models. In this
study\, we abandon the lattice needed to model the
cell positions in cellular automata modelling and
instead\, we apply a continuous cell-based approa
ch to simulate three-dimensional angiogenesis. Nex
t to the application of this modelling strategy to
angiogenesis\, we discuss the application of the
formalism to wound contraction.\n\nThe talk will d
escribe some of the mathematical issues encountere
d in these models and further some animations will
be shown to illustrate the potential merits of ou
r approaches.\n
LOCATION:Seminar Room 2\, Newton Institute Gatehouse
CONTACT:
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