University of Cambridge > > DAMTP BioLunch > Interkinetic nuclear migration as a stochastic process in the zebrafish retina

Interkinetic nuclear migration as a stochastic process in the zebrafish retina

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Recent work shows that some of the complexity of vertebrate tissues can be understood when stochastic processes are assumed to play a role in development. For example, in the zebrafish retina both the varying numbers of offspring from a single progenitor cell as well as the distributions of final cell fates have been explained using simple probabilistic models. We focus on interkinetic nuclear migration (IKNM), a type of nuclear movement that has been suggested to be involved in the regulation of retina cell fates and itself exhibits features of a stochastic process. Combining in vivo light sheet microscopy and mathematical modelling, we develop a quantitative description of IKNM . This description will enable an understanding of the involvement of IKNM in retina development regulation.

This talk is part of the DAMTP BioLunch series.

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