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Talk title: Microfluidic devices for blood analysis

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If you have a question about this talk, please contact Lorenzo Di Michele .

Physical properties of cells, such as, size, shape and deformability have recently generated a lot of interest as potential biomarkers for different diseases. For example, infection by the malarial parasites makes the infected red blood cells (RBCs) stiffer. Normally biconcave and deformable RBCs become sickle-shaped and stiffer in sickle cell anemia, thereby leading to vaso-occlusion in capillaries. My research group uses microfluidic technology to probe physical properties of cells to diagnose different blood-related disorders. In this talk I will briefly discuss two of our ongoing projects. The first project involves quantifying the shape change of red blood cells to detect sickle cell disease at the point of care. The second project describes a pillar-based microfluidic device to sort cells from whole blood. The final goal of both these projects is to develop portable and affordable microfluidic devices to bring disease diagnostics from the hospitals to the patient’s bedside.

This talk is part of the BSS Formal Seminars series.

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