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Cellular responses to DNA damage: mechanistic insights and therapeutic applications

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If you have a question about this talk, please contact Will Arter .

Very recent scientific and technological breakthroughs now allow researchers to study fundamental aspects of human cell biology with hitherto unimaginable depth, breadth and precision. Using paradigms derived from my academic laboratory – one of which has led to the drug olaparib/LynparzaTM that is being used to treat cancer patients worldwide – I will highlight how “blue skies” research into cell function can provide insights into disease mechanisms and identify new opportunities for alleviating cancer. I will also explain how the approaches that my laboratory uses may have utility in the context of human diseases associated with protein misfolding and/or aggregation.

This talk is part of the Biophysical Seminars series.

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