The Evolutionary Genomics of Staphylococcus aureus Infections

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• Prof Daniel Wilson, Big Data Institute, University of Oxford
• Wednesday 13 February 2019, 16:00-17:00
• Lecture Theatre 2, Department of Veterinary Medicine.

If you have a question about this talk, please contact Fiona Roby.

Like other major bacterial pathogens, S. aureus asymptomatically colonizes the human body far more frequently than it causes severe infections. This raises the question of what are the evolutionary and genetic differences between infection and asymptomatic colonization? To address this question we have sequenced and analysed S. aureus genomes to chart evolution within hundreds of healthy and infected patients, and to discover genetic differences associated with bacteria infecting and colonizing thousands of unrelated cases and controls. These studies reveal surprising differences in the genetic basis of different types of infection, and reveal signatures of bacterial adaptation within the human body to selection pressures that are as yet incompletely understood.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 2, Department of Veterinary Medicine
• Vet School Seminars

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