Synchronisation and alignment of mammalian motile cilia by hydrodynamic forces

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• Nicola Pellicciotta (University of Cambridge)
• Thursday 07 March 2019, 13:00-14:00
• MR11, Centre for Mathematical Sciences, Wilberforce Road, Cambridge.

If you have a question about this talk, please contact Anne Herrmann.

Motile cilia are widespread across the animal and plant kingdoms and often display complex collective dynamics which is central to their physiology. This talk will give an overview of the role of hydrodynamic forces in the ciliary beating coordination and orientation of multiciliated cells in mammalian tissues. I will present our recent results using controlled oscillatory external flows on multiciliated cells from brain ventricles. If the flow is strong enough and at a similar frequency to the actively beating cilia then it can entrain the cilia oscillations. Interestingly, this effect depends strongly on the number of cilia per cell. I will also show preliminary data using constant external flow on an in-vitro ciliogenesis culture of airway and brain ventricle ciliated cells.

This talk is part of the DAMTP BioLunch series.

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