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Synapse organizing mechanisms: from molecules to circuits

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Our research aims to mechanistically define how synapses are formed and remodeled. We have identified that synaptic adhesion molecules can guide and even instruct synapse development. One current research interest is to map the topography and dynamics of the synaptic cleft on a nanoscale. On a functional level, we additionally address how distinct synapse organizers cooperate to guide neuronal connectivity and how they control network maturation.

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