DENdrimicelles Dendrimer-Encapsulated-Nanoparticle coacervate-core Micelles

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• Prof. Dr. Aldrik Velders (Wageningen University & Research)
• Wednesday 08 May 2019, 14:00-15:00
• PfizerLecture Theatre, Department of Chemistry, Lensfield Road.

If you have a question about this talk, please contact Lingtao Kong.

Coacervate-core micelles constitute an important class of nanoaggregates, typically in the range of 50 – 100 nanometer, that are of interest for their application in material and biomedical sciences. We have developed a strategy to obtain insight in the formation, stability and properties of micelles, exploiting 5-10 nanometer PAMAM Dendrimer-Encapsulated Nanoparticles (DENs) as the core-building block, hence coined DENdrimicelles. The electron-dense nanoparticles allow for straightforward analysis by cryo-TEM of these hierarchical nanostructures over multiple length scales. Cryo-TEM of the DENdrimicelles provides insight in the periodicity of different generations of used dendrimers, the aggregation number of the corresponding micelles, insight in the core-properties, details on mesoscale organization, and surprising aspects on stability of thin-layers.

References. [1] Gomez, M. V.; Guerra, J.; Myers, V. S.; Crooks, R. M.; Velders, A. H. J. Am. Chem. Soc. 2009, 131, 14634. [2] Gomez, M. V.; Guerra, J.; Velders, A. H.; Crooks, R. M. J. Am. Chem. Soc. 2009, 131, 341– 350 [3] Ten Hove, J. B.; Wang, J.; van Leeuwen, F. W. B.; Velders, A. H. Nanoscale, 2017, 11, 18619. [4] Ten Hove, J. B.; Wang, J.; van Oosterom, M.; van Leeuwen, F. W. B.; Velders, A. H. ACS Nano, 2017, 11225. [5] Ten Hove, J. B.; van Oosterom, M. N.; van Leeuwen, F. W. B.; Velders, A. H. Sci. Rep., 2018, 13820. [6] ten Hove, J. B.; van Leeuwen, F. W. B.; Velders, A. H. Nat. Commun., 2018, 5207.

This talk is part of the Materials Chemistry Research Interest Group series.

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