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Genome remodelling in Streptococcus pyogenes

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If you have a question about this talk, please contact Fiona Roby.

I am a Royal Society and Wellcome Trust Sir Henry Dale Research Fellow. My laboratory is within the Department of Molecular Biology & Biotechnology, University of Sheffield and is also part of the Florey Institute for Host Pathogen Interactions. My research group focusses primarily on the pathogenesis of the human pathogen Streptococcus pyogenes through whole genome sequencing (WGS) and in vitro disease modelling. we identified a new variant within the genotype emm89 population that emerged having undergone recombination leading to increased NADase and Streptolysin O toxin expression and loss of the hyaluronic acid capsule. This new acapsular/high-toxin emm89 variant rose rapidly to dominance. More recently, we also identified that other genotypes have gone through similar genome-remodelling events towards an acapsular/high-toxin genotype/phenotype. I will present our findings and how we think these, and other, genetic changes contribute to the success of new streptococcal variants.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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