The enigma of histone 3 lysine 4 methylation

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• Prof. Francis Stewart; Professor of Genomics & Director of the Biotechnology Center, The Technical University of Dresden, Germany
• Wednesday 12 February 2020, 12:00-13:00
• Babraham - The Cambridge Building - The Petersfield Lecture Theatre.

If you have a question about this talk, please contact Bobbie Claxton.

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All active eukaryotic promoters are characterised by nucleosomes that are trimethylated on histone 3 lysine 4 (H3K4me3) and most mammalian enhancers display H3K4me1. Consequently current dogma contends that H3K4 methyltransferases operate as co-factors in transcriptional activation. Functional scrutiny does not sustain this dogma. In yeast, which has only one H3K4 methyltransferase – Set1C, originally described by my lab and also called COMPASS , loss of Set1C counterintuitively promotes more increased gene expression than reduced. In mammals, the six H3K4 methyltransferases have very specific, not general, functions in mouse development.

This talk is part of the Babraham Seminar series.

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