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Clinical Applications of Closed-loop Neural Interfaces

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Closed-loop neural interfaces use brain activity for real-time control of neurostimulation. In this talk, I will outline several therapeutic applications for such systems, from neuroprostheses that can replace damaged connections and promote activity-dependent plasticity, to closed-loop feedback for enhancing or suppressing oscillatory dynamics. I will describe different technologies for interfacing with the brain and spinal cord, including epidural spinal cuff electrodes to restore upper-limb function and optoelectronic implants for closed-loop optogenetics. In addition, I will show results of preclinical experiments with relevance to spinal cord injury, stroke and epilepsy.

This talk is part of the Electrical Engineering series.

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