Adult hippocampal neurogenesis in health and disease

Add to your list(s) Download to your calendar using vCal

• Dr Pascal Bielefeld; Swammerdam Institute for Life Sciences, University of Amsterdam, Netherlands
• Monday 24 February 2020, 12:00-13:00
• Babraham - The Cambridge Building - Kings Hedges Room.

If you have a question about this talk, please contact Bobbie Claxton.

If you would like to attend this seminar, please contact us to arrange site access

The extraordinary capacity of the rodent hippocampus to generate new neurons throughout life, a process known as adult hippocampal neurogenesis, has been a longstanding research topic. Over the years it has become clear that this strictly regulated process is crucial for several hippocampus-dependent phenomena, mostly related to memory formation and consolidation. Furthermore, deregulation of the hippocampal neurogenic cascade is a widely observed phenomenon in numerous pathologies. This reactive neurogenesis was thought to be a protective, regenerative intrinsic response from the brain, but over the years it has become clear that pathological stimuli can drive aberrant neurogenesis with detrimental consequences for the hippocampal stem cell niche and hippocampal functioning. Over the last 10 years our lab has been studying how adult hippocampal neurogenesis is regulated in both physiological and pathological conditions. In this talk I will discuss several highlights from the past years, spanning glucocorticoid-mediated preservation of neural stem cells during ageing to restoring seizure-induced aberrant neurogenesis using microRNAs, and our recent attempts to map Traumatic Brain Injury-induced alterations in the hippocampal stem cell niche using single cell RNA sequencing.

This talk is part of the Babraham Seminar series.

This talk is included in these lists:

• Babraham - The Cambridge Building - Kings Hedges Room
• Babraham Seminar
• Graduate-Seminars
• se393's list

Note that ex-directory lists are not shown.