Study virus assembly and host interactions in vitro and in cells by cryoEM and cryoET

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• Peijun Zhang, Professor of Structural Biology and Wellcome Trust Investigator, University of Oxford
• Tuesday 08 September 2020, 11:00-12:00
• Webinar via Zoom - https://zoom.us/j/97493748184?pwd=Z1dZM2pxUk16QytPeU5NVWZ3bnZmdz09 Meeting ID: 974 9374 8184 Passcode: 404662.

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With cryoEM, structures of purified proteins and protein complexes can be routinely determined to near-atomic resolution using single particle analysis (SPA) method. Structures of macromolecular complexes that are intrinsically flexible and non-homogeneous, and often function in higher-order assemblies that are difficult to purify, have recently been analyzed to near near-atomic resolution using cryo-electron tomography and sub-tomogram averaging (cryoET STA ). The study of these complexes and assemblies in cells using cryoET STA , coupled with cryoFIB and correlative imaging, opens a new frontier in structural cell biology. I will present our recent studies on HIV -1 capsid and its interaction with host factor cyclophilin A, cellular assembly of human reovirus and infection of SARS -Cov-2, to illustrate the power of integrated multiscale imaging from atoms to cells by cryo-electron microscopy.

This talk is part of the MRC LMB Seminar Series series.

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