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Dr Christina J. Sigurdson, Center for Veterinary Sciences and Comparative Medicine, UC San Diego 
Wednesday 28 April 2021, 16:00-17:00
Targeting protein aggregate clearance pathways to slow neurodegeneration in prion disorders
- 👤 Speaker: Dr Christina J. Sigurdson, Center for Veterinary Sciences and Comparative Medicine, UC San Diego 🔗 Website
- 📅 Date & Time: Wednesday 28 April 2021, 16:00 - 17:00
- 📍 Venue: Venue to be confirmed
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Fiona Roby
Abstract
Experimental studies indicate prion aggregates rapidly transit throughout the central nervous system, yet the relationship between the prion structure and genetic modifiers that impact aggregate spread are poorly understood. We and others previously showed profound differences in the neuroinvasion of prions, depending on the strain. Using a series of established and new mouse models to alter the extracellular matrix or the prion protein, we investigated the determinants of prion propagation through the neuron and through the CNS .
Chaired by Dr Raymond Bujdoso
Series This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.
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- Venue to be confirmed
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