Abstract

Abstract: This talk will present data on the neurobiological mechanisms underlying psychosis from imaging studies in patients with schizophrenia and bipolar disorder, as well as from people at high and low genetic risk. Data from a preclinical model that reproduces the imaging findings and the evaluation of a novel non-D2 treatment target will be presented. Finally, treatment resistance and outstanding questions will be considered.

Biography: Oliver Howes is Professor of Molecular Psychiatry at the Institute of Psychiatry, Psychology and Neuroscience, King’s College, London and Programme Leader at the MRC London Institute of Medicine, Imperial College, London. His clinical work is as Consultant Psychiatrist at The Maudsley Hospital, where he runs a service for people with psychoses. His research interests centre on the causes and treatment of affective and psychotic disorders. His recent work has focussed on understanding the role of dopamine and neuroinflammation in the development of psychosis, the effects of antipsychotic drugs, & the causes of cognitive impairments. For detailed biography of Prof Howes, please visit: https://www.kcl.ac.uk/people/oliver-howes and https://www.imperial.ac.uk/people/oliver.howes