University of Cambridge > Talks.cam > Morphogenesis Seminar Series > Morphogenesis of the mouse and human embryo beyond implantation

Morphogenesis of the mouse and human embryo beyond implantation

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  • UserMatteo Molè
  • ClockMonday 24 May 2021, 14:30-15:30
  • HouseOnline.

If you have a question about this talk, please contact Elena Scarpa.

https://zoom.us/j/95435060718?pwd=QzIyS0FTcXF3LzlkT2RiVjdmZDhYUT09

During the transition from pre-implantation to early post-implantation the mammalian embryo undergoes major morphogenetic changes, leading to transformation of the blastocyst into the egg-cylinder or bilaminar disk configuration, in mouse or human respectively. We found that integrin 1 is required during this transition, coordinating morphogenesis and promoting survival of the embryo proper. By single cell RNAseq, we also characterised a sequence of events underlying post-implantation development of the human embryo. We identified a group of cells which may act as an evolutionary-conserved anteriorising signalling centre for the establishment of the anterior-posterior axis prior to gastrulation.

This talk is part of the Morphogenesis Seminar Series series.

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