University of Cambridge > Talks.cam > Seminars at the Department of Biochemistry > Tea Club Seminar - Ritwick Sarwarkar - "Host chromatin response to SARS-CoV-2 et al"

Tea Club Seminar - Ritwick Sarwarkar - "Host chromatin response to SARS-CoV-2 et al"

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A variety of environmental stressors, infections and neurodegenerative conditions cause global transcriptional downregulation inhuman cells, a phenomenon we termed as Stress-Induced Transcriptional Attenuation (SITA). In the talk, I will discuss our work on understanding the mechanism underlying SITA that has led us to uncover novel nuclear condensates formed by liquid-liquid phase separation. Similar transcriptional downregulation is also seen in lung cells upon SARS -CoV-2 infection, identifying therapeutic avenues.

This talk is part of the Seminars at the Department of Biochemistry series.

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