Estimating global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis using genetic data.

Add to your list(s) Download to your calendar using vCal

• Noemie Lefrancq (University of Cambridge)
• Wednesday 04 May 2022, 16:00-17:00
• Zoom.

If you have a question about this talk, please contact Dr Ciara Dangerfield.

Bordetella pertussis (Bp), which causes whooping cough, infects >24 million individuals annually despite widespread vaccination. Asymptomatic carriage and multiple circulating lineages hide the underlying dynamics of Bp from surveillance systems. Therefore, the extent of spread across spatial scales remains a mystery, as does the role of vaccines in driving changes in strain fitness. Models informed by pathogen sequences can help. In this seminar I will present how models informed by >3300 genomes shed light on Bp spatial structure, rate of geographic spread, and fitness shifts in response to vaccine changes. Link to the paper: https://www.science.org/doi/10.1126/scitranslmed.abn3253

This talk is part of the Worms and Bugs series.

This talk is included in these lists:

• All CMS events
• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Diseases
• Worms and Bugs
• Zoom
• bld31

Note that ex-directory lists are not shown.