LMB Seminar: Mechanism and regulation P element transposition in Drosophila

Add to your list(s) Download to your calendar using vCal

• Donald Rio, Professor of Biochemistry, Biophysics and Structural Biology, Dept. of Molecular and Cell Biology, University of California, Berkeley, USA
• Tuesday 29 November 2022, 16:00-17:00
• In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94108711681?pwd=cXN4VGlQVHBZYkpMUVJ0SXV3emtaUT09.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

Transposable elements are ubiquitous in the genomes of all known organisms from bacteria to humans. These mobile genetic elements are known to contribute to genome evolution and organization. P elements were discovered in the fruit fly, Drosophila melanogaster, because they cause a genetic syndrome called hybrid dysgenesis where their uncontrolled mobility leads to sterility, mutations and chromosomal rearrangements. P elements are mobilized using a cut-and-paste mechanism by a DNA binding transposase enzyme that uses GTP as a cofactor at multiple stages of the reaction pathway. The interaction of P elements with their host has led to multiple regulatory strategies to regulate and restrict P element mobility to the germline involving alternative pre-mRNA splicing and the small piwi-interacting RNA (piRNA) pathway. Genome sequencing has identified P element transposase-related genes, called THAP9 , found in vertebrate genomes. I will discuss mechanistic studies of P element transposition and how transposition is regulated

This talk is part of the MRC LMB Seminar list series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• CSIC Research Talk
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94108711681?pwd=cXN4VGlQVHBZYkpMUVJ0SXV3emtaUT09
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar list
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• rc781

Note that ex-directory lists are not shown.