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LMB Seminar: Tissue genomics: High throughout tools for measuring and perturbing tissues

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Tissue functions are highly cell non-autonomous. While single-cell analysis has begun to elucidate the cellular components that participate in tissue function and dysfunction; interactions—and their spatial variation across tissue structures—remain challenging to explore. Here, we’ll describe advances in single cell spatial multi-omic tools which aim to capture both the spatial context of cells as well as their dynamics within tissues. We will describe efforts to apply these tools to measure, model and manipulate the rules of tissue organization, including a novel method for programmable RNA sensing in mammalian cells. More broadly, we’ll discuss the promise and challenges of spatial transcriptomics for tissue genomics

This talk is part of the MRC LMB Seminar Series series.

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