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Building and Breaking the Neural Tube

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  • UserClare Buckley (PDN, University of Cambridge)
  • ClockMonday 20 February 2023, 14:30-15:30
  • HouseOnline.

If you have a question about this talk, please contact Elena Scarpa .

https://us06web.zoom.us/j/82089026611?pwd=L2FyclJFL2lYR0J3SFBDbHQyUFp6UT09 

My lab investigates the morphogenesis of epithelial tubes during development and disease. Broadly, we want to know how epithelial tubes first polarise, how they open (rather than close) and why they break during disease. We are currently particularly interested in understanding the links between cell-cell adhesion, actomyosin contractility and cellular mechanics during secondary neurulation. To investigate these processes, we use high resolution imaging, CRISPR and optogenetics approaches in vivo, with the developing zebrafish neural tube and in vitro, within multicellular mouse embryonic stem cell cultures.

This talk is part of the Morphogenesis Seminar Series series.

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