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BSU Seminar: 'Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection'

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  • UserMélanie Prague, Inria, University of Bordeaux
  • ClockTuesday 23 May 2023, 14:00-15:00
  • HouseOnline Seminar.

If you have a question about this talk, please contact Alison Quenault .

This will be a free online seminar. To register to attend, please click here: https://us02web.zoom.us/meeting/register/tZUuf-usqDovGdf1TbAtYgsGCRJmoz0Hmbfi

The definition of correlates of protection is critical for the development of next generation SARS -CoV-2 vaccine platforms. Here, we propose a model-based approach for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics and data mining of immunological markers. The application to three different studies in non-human primates evaluating SARS -CoV-2 vaccines based on CD40 -targeting, two-component spike nanoparticle and mRNA 1273 identifies and quantifies two main mechanisms that are a decrease of rate of cell infection and an increase in clearance of infected cells. Inhibition of RBD binding to ACE2 appears to be a robust mechanistic correlate of protection across the three vaccine platforms although not capturing the whole biological vaccine effect. The model shows that RBD /ACE2 binding inhibition represents a strong mechanism of protection which required significant reduction in blocking potency to effectively compromise the control of viral replication.

Based on elife paper https://doi.org/10.7554/eLife.75427

This talk is part of the MRC Biostatistics Unit Seminars series.

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