Abstract

This is a free symposium, but please contact the organiser should you wish to attend as numbers are limited. Registration by email is compulsory.

• DNA Damage-activated Kinases as Cancer Therapeutic Targets Prof Roger J. Griffin School of Chemistry, Northern Institute for Cancer Research

• Chemists and the Drug Discovery and Development Process Dr Martin Swarbrick, Cancer Research Discovery Laboratories, Cambridge

• The Role of Pharmacologists in Cancer Drug Development Prof Duncan Jodrell, Professor of Cancer Therapeutics, Department of Oncology

• Fragment-Based Methods for Drug Discovery Prof Chris Abell, Professor of Biological Chemistry, Department of Chemistry

Student Talks

• Synthesis of Cyclopamine and Analogues
• The Synthesis and Biological Evaluation of Uncinatone – A Member of the Abietane Diterpenoid Class of Small Molecules
• Fragment-Based Approach to the Discovery of Polo-Box Domain Binding Inhibitors of Polo-like Kinase-1
• Destroying Tumour Vasculature: Marine Natural Products as Starting Points for Drug Discovery
• Combating Chemoresistance in Glioblastoma: Interaction of Small Molecules with the Direct Reversal DNA Repair Pathway
• Augmenting Ligand Efficiency: Exploiting the Properties of Heavy Metals in Medicinal Chemistry
• Disrupting Cellular Microtubules: Synthesis and Biological Investigation of Bromotyrosine Derived Natural Products as Potential Anticancer Agents
• Investigation of the Effect of Small Molecules on Chromatin Modification
• The Development of Novel Targeted Imaging Agents
• The Biological Response of Caspase-4 to Tumour Necrosis Factor-α
• Chemical Targeting of Kinases in Drug Resistant Prostate Cancer
• Investigating the Interaction Between the Pluripotency Lin-28 and the microRNA (miRNA) Let-7