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Understanding cell alignment: from two interacting cells to collective behaviour

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MMVW03 - Measures and Representations of Interactions

In this work we investigate the mechanisms behind the long range alignment of ellipse shaped cells, motivated by experimental observations of fibroblast alignment in fibrotic tissue. We start by deriving and simulating an agent based model that incorporates physical, force based interactions between cells, and then extend the model to account for shape changes and cell-cell junctions. Analytical techniques can be used to understand the alignment properties of the model for two interacting cells under certain symmetry conditions. We can then simulate the full model to explore whether our analytical results are reflected in the collective behaviour of the system. 

This talk is part of the Isaac Newton Institute Seminar Series series.

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