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Collective migration of epithelial cells: from animal to lab, and back

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SPLW02 - Active mechanics, from single cells to cell layers, tissues and development

The fruit fly larva is a maggot which looks like a dull white cylinder. Within a few days, and without any changes in its genome sequence, it metamorphoses. It gets its sophisticated adult fly shape with wings, legs, antennas, and compound eyes. How do cells migrate, deform, and rearrange to shape a tissue?To approach step by step the dynamics of this morphogenesis, we will journey from developmental biology to mechanics, from discrete description of cellular material to continuum mechanics quantification, and from experiments to modeling. We will investigate flows within geometries specifically designed to discriminate between models.

This talk is part of the Isaac Newton Institute Seminar Series series.

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Biochemistry Lecture Theatre, Sanger Building Recital Room, Churchill College, Storey’s Way, Cambridge. CB3 0DS Webinar & LT2, Computer Laboratory, William Gates Building.

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