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Professor Sir Peter Ratcliffe FRS, Distinguished Scholar, Ludwig Institute for Cancer Research, University of Oxford and Clinical Research Director, Francis Crick Institute, London.
Wednesday 06 March 2024, 18:00-19:00
HONORARY FELLOWS LECTURE - Every breath you take and every move you make - understanding cellular oxygen sensing mechanisms
- 👤 Speaker: Professor Sir Peter Ratcliffe FRS, Distinguished Scholar, Ludwig Institute for Cancer Research, University of Oxford and Clinical Research Director, Francis Crick Institute, London.
- 📅 Date & Time: Wednesday 06 March 2024, 18:00 - 19:00
- 📍 Venue: Bristol-Myers Squibb Lecture Theatre, Department of Chemistry
Abstract
The maintenance of oxygen homeostasis is a key physiological challenge, inadequate oxygen (hypoxia) being a major component of most human diseases. The lecture will trace insights into human oxygen homeostasis from the founding work of William Harvey on the circulation of the blood to the molecular elucidation of a system of oxygen sensing that functions to measure oxygen levels in cells and control adaptive responses to hypoxia. The lecture will outline how the oxygen sensitive signal is generated by a set of ‘oxygen splitting’ enzymes that modify a transcription factor (HIF) to signal for its degradation (and hence inactivation). It will attempt to illustrate and rationalise the unexpected in biological discovery and discuss the interface of discovery science with the development of medical therapeutics.
Series This talk is part of the Cambridge Philosophical Society series.
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