Abstract

Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan. Prof. Cleo Bishop is the Director of the Queen Mary University of London Phenotypic Screening Facility and a group leader, whose research focuses on molecular mechanisms of senescence and ways to minimise it as a means of cellular rejuvenation. Her group has developed a novel screening platform for the expedited discovery of compounds that restrain cellular ageing in vitro and enable extension of in vivo lifespan. Their method expands the scope of CpG methylation profiling to accurately and rapidly detecting anti-ageing potential of drugs using human cells in vitro and in vivo. This provides a novel accelerated discovery platform to test sought after anti-ageing compounds and geroprotectors.